Search for TB-500 peptide online and you will often see it described simply as “Thymosin Beta-4.” There is just one problem: they are not the same molecule.
For laboratories and professional peptide buyers, understanding that difference is essential before comparing suppliers, purity claims or Certificates of Analysis.
What Is TB-500?
TB-500 (CAS 885340-08-9) is a synthetic, N-terminally acetylated heptapeptide corresponding to residues 17–23 of human Thymosin Beta-4.
Its sequence is:
Ac-Leu-Lys-Lys-Thr-Glu-Thr-Gln (Ac-LKKTETQ)
TB-500 is therefore a 7-amino-acid Thymosin β4 fragment, while full-length Thymosin Beta-4 contains 43 amino acids.
They should not be treated as interchangeable research materials.
TB-500 vs. Thymosin Beta-4: Why the Difference Matters
This distinction is particularly important when reading research online.
Much of the published literature discussing Thymosin Beta-4 involves the full-length parent molecule, including experimental research related to actin dynamics, cellular migration and tissue-remodeling pathways.
The direct evidence base for the TB-500 fragment itself is much smaller.
For researchers, this means a supplier should clearly identify whether the material is:
Full-length Thymosin Beta-4
or
TB-500 / Ac-LKKTETQ / Thymosin β4 Fragment 17–23
Mixing the two can create problems for literature review, experimental design and material verification.
What Do Online TB-500 Reviews Say?
Online experiences involving TB-500 are highly inconsistent.
Some users report perceived improvements involving discomfort or recovery.
Others report no noticeable benefit or unwanted experiences such as fatigue, brain fog, headaches or other symptoms. More serious reactions have also been described in individual online reports.
These anecdotes cannot establish safety or efficacy.
Many reports also involve BPC-157 or other compounds at the same time, while peptide identity, purity and contamination cannot usually be independently verified.
For professional research, analytical documentation is more useful than anecdotal reviews.
Choosing a TB-500 Supplier: Verify the Molecule First
Before comparing prices between TB-500 suppliers, consider four basic questions.
1. Is It Actually TB-500?
Check the sequence.
TB-500 should correspond to:
Ac-LKKTETQ
The applicable chemical form should also match the batch documentation.
2. Is HPLC Purity Available?
TB-500 HPLC data can provide information about relative purity and the impurity profile.
But remember:
High HPLC purity does not by itself prove molecular identity.
3. Is Identity Testing Available?
Where applicable, mass spectrometry or other identity information can provide additional evidence that the supplied peptide corresponds to the expected molecular species.
4. Is the COA Batch-Specific?
A professional TB-500 Certificate of Analysis should correspond to the actual production lot.
B2B buyers may consider reviewing:
- HPLC purity;
- identity or MS information where applicable;
- batch/lot number;
- peptide specifications;
- SDS;
- storage conditions;
- traceability documentation.
TB-500 Research Peptide from Sunone
Sunone (Hong Kong) Biopharmaceutical International Technology Co., Limited supplies TB-500 for qualified laboratory research and manufacturing applications.
Current product information includes:
Product: TB-500
Synonyms: TB500 / Ac-LKKTETQ / Thymosin β4 Fragment 17–23
CAS: 885340-08-9
Sequence: Ac-Leu-Lys-Lys-Thr-Glu-Thr-Gln
Molecular Weight: 889.0 g/mol
Purity: ≥99.1% by HPLC
Form: Lyophilized Powder
Documentation: COA, SDS and Specification Sheet available
Looking for high-purity TB-500 research peptide, batch documentation or B2B quantities?
View TB-500 Specifications ：
Send Sunone your required quantity, packaging, specifications and analytical-documentation requirements for a B2B quotation.
TB-500 FAQ
Is TB-500 the same as Thymosin Beta-4?
No. TB-500 commonly refers to an acetylated 7-amino-acid fragment corresponding to residues 17–23 of Thymosin Beta-4. Full-length Thymosin Beta-4 is a larger molecule.
What is the TB-500 sequence?
The sequence is Ac-Leu-Lys-Lys-Thr-Glu-Thr-Gln (Ac-LKKTETQ).
What is the CAS number of TB-500?
Sunone lists TB-500 free base as CAS 885340-08-9.
What should B2B buyers request from a TB-500 supplier?
Professional buyers may consider reviewing batch-specific COA, HPLC purity, identity information, specifications, SDS and lot traceability.
Where can I request TB-500 research peptide specifications?
Qualified B2B buyers can review the Sunone TB-500 product page and submit their quantity and documentation requirements for quotation.
This content is provided for scientific and educational purposes only. SUNONE research peptide is for qualified labrtorynt, diagnois, druc tor mmatct or veteimant, use.research only, Not for human consumption, clinical treame. Purchasers are responsible for complying with applicable laws and regulations in their jurisdiction.
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