MOTS-c is only 16 amino acids long. That does not mean its identity should be reduced to a product name and one purity percentage.
For professional research buyers, the important question is:
Does the batch documentation define the exact MOTS-c molecule being supplied?
That includes sequence, molecular identity, terminal form, counterion or salt form, purity and lot-specific analytical data.
What Is MOTS-c?
MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a 16-amino-acid mitochondrial-derived peptide investigated in mitochondrial signaling and metabolic-stress research.
The commonly reported human sequence is:
MRWQEMGYIFYPRKLR
Common identifiers for the parent peptide include:
CAS: 1627580-64-6
Molecular Formula: C101H152N28O22S2
Molecular Weight: approximately 2174.6 g/mol
MOTS-c research has attracted attention in areas involving cellular energy metabolism, mitochondrial-to-nuclear signaling, stress adaptation and AMPK-related pathways.
But biological interest does not replace analytical identity.
“MOTS-c” Is a Name—not a Complete Batch Specification
For a sequence-defined peptide, buyers should be able to connect several pieces of information:
Product name → sequence → termini → molecular mass → chemical form → analytical result
Why?
Because a peptide may be supplied or referenced in different counterion or salt forms.
A molecular-weight specification appropriate for the parent molecule should not automatically be treated as the molecular weight of every possible salt-containing form.
For laboratories performing quantitative or identity-sensitive research, that distinction can matter.
Sequence Comes Before the Purity Percentage
An HPLC purity result can help describe how much of the chromatographic material corresponds to the principal component.
But ≥99% HPLC does not independently prove which peptide that principal peak represents.
For MOTS-c sourcing, professional buyers may therefore ask:
Does the COA specify the 16-aa sequence?
Is the expected molecular mass supported by appropriate MS or LC-MS data?
Are the peptide termini defined?
Is the salt or counterion form identified where relevant?
Does the HPLC chromatogram correspond to this actual lot?
These questions separate purity from identity.
Why Salt Form Can Change the Number on the Specification
MOTS-c is often discussed simply by its peptide name.
However, database records and commercial specifications may distinguish the parent peptide from salt-containing forms such as TFA-associated material.
That can alter formula weight and analytical interpretation.
For B2B procurement, a molecular-weight number is therefore most useful when the corresponding chemical form is also defined.
A better quality chain is:
Sequence → Terminal Form → Salt/Counterion → Molecular Mass → HPLC → MS/LC-MS → Batch COA
Endogenous MOTS-c and Synthetic Research MOTS-c Are Different Questions
MOTS-c is described as a mitochondrial-derived peptide because the endogenous peptide is encoded within the mitochondrial genome.
A synthetically manufactured research peptide can reproduce the intended amino-acid sequence.
But the phrase “mitochondrial-derived” does not itself verify a synthetic vial.
The synthetic research material still requires normal analytical confirmation of:
- sequence identity;
- chemical form;
- purity;
- related impurities;
- batch consistency;
- lot traceability.
The biological origin of the endogenous molecule and the analytical quality of a manufactured research material should not be confused.
What Do MOTS-c Reviews Say?
Online experiences are mixed.
Positive anecdotal comments sometimes mention perceived:
- energy;
- exercise endurance;
- workout quality;
- sleep or recovery.
Negative reports include:
- fatigue;
- local skin reactions;
- itching;
- flushing;
- anxiety or irritability;
- brain fog;
- palpitations;
- no noticeable effect.
These reports do not establish MOTS-c safety, efficacy or material quality.
Most online accounts do not independently verify the peptide source, sequence, purity, chemical form, concurrent substances or individual health conditions.
What Should a B2B Buyer Verify?
When comparing a MOTS-c supplier, professional laboratories may consider reviewing:
Exact Sequence
Confirm the intended 16-amino-acid MOTS-c sequence.
Chemical Form
Verify terminal form and relevant salt or counterion information.
HPLC Purity
Understand what the reported purity measurement represents.
MS / LC-MS Identity Data
Where appropriate, confirm that observed mass supports the expected molecular species.
Impurity Information
Review relevant peptide-related substances or degradation products.
Batch-Specific COA
Generic specifications should not replace documentation for the actual production lot.
Lot Traceability
The vial, lot number, COA and analytical records should correspond to the same batch.
MOTS-c Research Peptide from Sunone
Sunone (Hong Kong) Biopharmaceutical International Technology Co., Limited supplies MOTS-c for qualified laboratory research and biotechnology manufacturing applications.
Current listed product information includes:
Product: MOTS-c
Synonyms: MOTS-c (Human) / Mitochondrial Open Reading Frame of the 12S rRNA-c
CAS: 1627580-64-6
Molecular Formula: C101H152N28O22S2
Molecular Weight: approximately 2174.6 g/mol
Grade: Research Grade
Form: Lyophilized Powder
Storage: 2–8°C, protected from light
Documentation: Batch-specific COA, SDS and Specification Sheet available
Current listed formats include:
10 mg × 10 vials
20 mg × 10 vials
40 mg × 10 vials
Exact sequence, termini, salt form, purity and analytical characteristics should always be confirmed against the current batch-specific documentation.
Looking for a MOTS-c supplier with B2B analytical documentation?
View Sunone MOTS-c Specifications ：
Contact Sunone with your required quantity, analytical-documentation requirements, packaging format and OEM/ODM project specifications for a current quotation.
FAQ
What is the MOTS-c sequence?
The commonly reported human MOTS-c sequence is MRWQEMGYIFYPRKLR, a 16-amino-acid peptide.
What is the CAS number for MOTS-c?
MOTS-c is commonly associated with CAS 1627580-64-6.
Is MOTS-c a mitochondrial-derived peptide?
Endogenous MOTS-c is described as a mitochondrial-derived peptide encoded within the mitochondrial 12S rRNA region.
Does “mitochondrial-derived” prove the identity of synthetic MOTS-c?
No. A manufactured research peptide still requires analytical identity verification.
Does ≥99% HPLC prove a vial contains the correct MOTS-c?
Not by itself. Chromatographic purity and molecular identity are different analytical questions.
Why should MOTS-c salt form be specified?
Counterion or salt form can affect formula weight and analytical interpretation, so chemical form should be consistent with the applicable COA and identity data.
This content is provided for scientific and educational purposes only. SUNONE research peptide is for qualified labrtorynt, diagnois, druc tor mmatct or veteimant, use.research only, Not for human consumption, clinical treame. Purchasers are responsible for complying with applicable laws and regulations in their jurisdiction.
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